The risk of acute kidney disease is doubled for people taking oral fluoroquinolone antibiotics, according to a study Fluoroquinolones, including levofloxacin, ciprofloxacin, and moxifloxacin, are common broad-spectrum antibiotics most often used to treat urogenital and respiratory infections. The case reports have indicated that prescription labels and acute kidney injury with use, carry a warning of kidney failure. Kidney injury is usually not considered when oral fluoroquinolones are prescribed in clinical practice. People who had a history of dialysis or chronic kidney disease increase the risk of acute injury.
The researchers found that current use of oral fluoroquinolones increased the risk of acute kidney injury; the risk was highest with ciprofloxacin, followed by moxifloxacin.They also found that concurrent use of a popular class of cardiovascular medication such as oral fluoroquinolone and a renin-angiotensin-system blocker, increases the risk of acute renal failure by 4.5 fold. The twofold differential in risk between current and both recent and past fluoroquinolone use suggests that acute kidney injury is an acute adverse effect of fluoroquinolones.
They also suggest that physicians need to be aware of the risks of kidney injury when prescribing these drugs. It is although clear that the risk of death due to serious infections outweighs the risks associated with the use of it. They conclude that the potential for acute kidney injury raises the importance of vigilant prescribing.
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Balfour Morris is a Medical Student and a freelancer who is specialized in writing. He is associate with many Pharmacies for whom he writes news based on generic drugs and general health related issues.